en سلامت Health Original Article <strong>Background:</strong> COVID-19 has increased drastically all over the world and one of the major ways to reduce its prevalence is through COVID-19 vaccine. However, some individuals hesitate in accepting the uptake of the COVID-19 vaccine which is a major cause of concern to the global health.<br> <strong>Method:</strong> this cross-sectional study was conducted on450 respondents were selected through networking system in Lagos state. The COVID-19 Hesitancy Questionnaire with reliability value of 0.67 was used as instrument for data collection. Data gathering was online through Google docs which was circulated via e-mail and WhatsApp platform to the participants. Data Analyzing was done via SPSS 20<br> <strong>Results:</strong> The study revealed that 92% were aware of the accessibility of vaccine for COVID-19. Totally, 81.11% had not received the vaccine and the reasons given include misconceptions on the effects of the COVID-19.<br> <strong>Conclusions:</strong> COVID-19 vaccine uptake is generally poor among the uneducated than the educated. Therefore, there is need for massive education on the importance of COVID-19 among the populace especially among the less educated. COVID-19, COVID-19 Vaccine, Global Health, Vaccine Hesitancy 713 718 http://sbrh.ssu.ac.ir/browse.php?a_code=A-10-256-2&slc_lang=en&sid=1 Fasoranti Afolabi Joseph afasoranti@unilag.edu.ng 4521363586 0000-0003-4196-0801 Yes Department of Human Kinetics and Health Education, University of Lagos, Nigeria.